Evidence for an important role of host microRNAs in regulating hepatic fibrosis in humans infected with &ITSchistosoma japonicum&IT

authors

• Cabantous Sandrine
• Hou Xunya
• Louis Laurence
• He Hongbin
• Mariani Odette
• Sastre Xavier
• Daujat-Chavanieu Martine
• Li Yuesheng
• Dessein Alain

keywords

• Expression analysis
• Schistosoma japonicum
• Human schistosomiasis
• MicroRNA
• Liver fibrosis

abstract

MicroRNAs (miRNAs) are short, non-coding RNAs that repress the translation of target gene transcripts. They have been implicated in various activities such as cell proliferation, survival, differentiation, migration and metabolism. We report here the first known miRNome and transcriptome analysis of human livers displaying advanced fibrosis due to Schistosoma japonicum infection. We present evidence that hsa-miR-150-5p, hsa-miR-10a-5p, hsa-miR-199a-3p, hsa-miR-4521, hsa-miR-222/221, hsa-miR-663b and hsa-miR-143-3p (associated without correction) play an important role in hepatic fibrosis by acting on metabolism, organization of the extracellular matrix proteins, lipid mobilization and limitation of oxidative damage stress. (C) 2017 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.

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