Caffeine and adenosine receptors control multicellular processes leading to memory deficits in Alzheimer’s Disease
Epidemiological and experimental studies including ours support the beneficial effect of habitual caffeine consumption in Alzheimer's Disease (AD). The underlying mechanisms remain however ill-defined but are thought to depend on its ability to block adenosine A2A receptors, found upregulated in hippocampal neurons and astrocytes of AD patients. The present seminar will highlight recent data from our group that demonstrate the ability of caffeine to control neuro-glial mechanisms linked to hippocampal memory. Moreover, the multicellular consequences of adenosine receptor upsurge found in the AD brain and unveiled using the combination of transgenic, 3D morphological and transcriptomic approaches, will be discussed together with the subsequent translational developments.
