The fourth dimension of our universe remains elusive. To date, no one is able to define time or explain why, unlike the three other dimensions, it is unidirectional. However, even in the absence of calendars, our bodies live and vibrate to the rhythm of internal chronometers called circadian clocks.
Profound shifts in our body clock can be observed in teenagers, elderly people or patients with cerebral diseases. The team's mission is to study the roles of genes and proteins involved in circadian rhythms or in neurodevelopmental (autism spectrum disorders, Prader Willi syndrome) and neurodegenerative (Alzheimer’s disease) pathologies.
GRAN team focuses on
- 3 major topics: time windows, plasticity and time-associated brain diseases
- 4 issues: hormones/steroids, synapses, cerebral chemoreceptors and non-coding RNAs
- 4 tools and techniques: animal behaviour, bioinformatics and genomic imprinting, immunochemistry.
1. Further characterize the molecular mechanisms involved in the control of circadian gene expression, especially those involving lncRNAs such as Neat1 or Malat1
2. Improving our knowledge on the pathophysiology of the Prader Willi syndrome and its related circadian anomalies and identifying the genes involved in these dysfunctions
3. Uncovering the roles and mechanisms of action/regulation of MOCOS and its associated molecules in the overall neurodevelopmental processes, especially in autistic patients
PIs : F. Feron & B. Gepner