Genes, Rhythm and Neurophysiopathology

Description: 

The fourth dimension of our universe remains elusive. To date, no one is able to define time or explain why, unlike the three other dimensions, it is unidirectional. However, even in the absence of calendars, our bodies live and vibrate to the rhythm of internal chronometers called circadian clocks.

Profound shifts in our body clock can be observed in teenagers, elderly people or patients with cerebral diseases. The team's mission is to study the roles of genes and proteins involved in circadian rhythms or in neurodevelopmental (autism spectrum disorders, Prader Willi syndrome) and neurodegenerative (Alzheimer’s disease) pathologies.

GRAN team focuses on:

  • 2 major topics: time windows, plasticity and time-associated brain diseases
  • 4 issues:  hormones/steroids, synapses, cerebral chemoreceptors and non-coding RNAs
  • 4 tools and techniques: animal behaviour, bioinformatics and genomic imprinting, immunochemistry.

 

Public Summary: 

" For a better understanding of life’s rhythms "

 

The team's research focuses on the molecular mechanisms of biological rhythms and on neuro-developmental or neurodegenerative pathologies that are associated with alterations in these rhythms.

While to date no one is able to define time or explain why, unlike the three other dimensions, it is unidirectional, it is known that even in the absence of calendars, our bodies live and vibrate to the rhythm of internal chronometers called circadian clocks.

Profound shifts in our body clock can be observed in teenagers, elderly people or patients with cerebral diseases. The team's mission is to study the roles of genes encoding or not proteins in circadian rhythms or pathologies associated with circadian dysfunctions (autism spectrum disorders, Prader Willi syndrome, Alzheimer’s disease).

Research topics: 

1. Further characterize the molecular mechanisms involved in the control of circadian gene expression, especially those involving lncRNAs such as Neat1 or Malat1

2. Improving our knowledge on the pathophysiology of the Prader Willi syndrome and its related circadian anomalies and identifying the genes involved in these dysfunctions

 

 

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Image icon amfbteam.png7.71 MB

News

  1. Anne-Marie François Bellan
    Listening to our molecular clocks

    During the NeuroStories event, held on Monday October 7 at the Faculty of Medicine, Anne-Marie François Bellan gave a remarkable stand up on how our body vibrates to the rhythm of internal chronometers called circadian clocks. She also explained how the molecular clock uses small corpuscles and cell space to make our genes rhythm. The video of his speech and those of the other six speakers will be available very soon.

Highligthed Publications

Team Publications