Genes, Rhythm and Neurophysiopathology

Team leader: 

The fourth dimension of our universe remains elusive. To date, no one is able to define time or explain why, unlike the three other dimensions, it is unidirectional. However, even in the absence of calendars, our bodies live and vibrate to the rhythm of internal chronometers called circadian clocks.

Profound shifts in our body clock can be observed in teenagers, elderly people or patients with cerebral diseases. The team's mission is to study the roles of genes and proteins involved in circadian rhythms or in neurodevelopmental (autism spectrum disorders, Prader Willi syndrome) and neurodegenerative (Alzheimer’s disease) pathologies.

GRAN team focuses on

  • 3 major topics: time windows, plasticity and time-associated brain diseases
  • 4 issues:  hormones/steroids, synapses, cerebral chemoreceptors and non-coding RNAs
  • 4 tools and techniques: animal behaviour, bioinformatics and genomic imprinting, immunochemistry.
Research topics: 

1. Further characterize the molecular mechanisms involved in the control of circadian gene expression, especially those involving lncRNAs such as Neat1 or Malat1

PIs : A.M. François-Bellan & J.L. Franc

2. Improving our knowledge on the pathophysiology of the Prader Willi syndrome and its related circadian anomalies and identifying the genes involved in these dysfunctions

PIs : A.M. François-Bellan & D. Becquet

3. Uncovering the roles and mechanisms of action/regulation of MOCOS and its associated molecules in the overall neurodevelopmental processes, especially in autistic patients

PIs : F. Feron & B. Gepner

4. Understanding, using a mouse model of Alzheimer’s disease, the roles of cerebral chemoreceptors and further characterizing the mechanisms underlying circadian/sleep dysregulation and neurodegeneration

PIs : G. Guiraudie-Capraz, F. Féron & A.M. Francois-Bellan

Team Publications