Targeting Adrenomedullin in Oncology: A Feasible Strategy With Potential as Much More Than an Alternative Anti-Angiogenic Therapy

authors

  • Vázquez Ramiro
  • Riveiro Maria E
  • Berenguer-Daize Caroline
  • O’kane Anthony
  • Gormley Julie
  • Touzelet Olivier
  • Rezai Keyvan
  • Bekradda Mohamed
  • Ouafik L'Houcine

keywords

  • Adrenomedullin
  • Angiogenesis
  • Cancer
  • Metastasis
  • AM 1 and AM 2
  • RAMP1-3

abstract

tumor angiogenesis, metastasis and growth following treatment with AM-neutralizing antibodies, AM receptor antagonists, or AM receptor interference. Anti-AM therapy is a promising strategy to be explored in oncology, not only as an anti-angiogenic alternative in the context of acquired resistance to VEGF treatment, but also as a potential antimetastatic approach.

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