High-grade gliomas in adolescents and young adults highlight histomolecular differences from their adult and pediatric counterparts

authors

• Roux Alexandre
• Pallud Johan
• Saffroy Raphaël
• Edjlali-Goujon Myriam
• Debily Marie-Anne
• Boddaert Nathalie
• Sanson Marc
• Puget Stéphanie
• Knafo Steven
• Adam Clovis
• Faillot Thierry
• Cazals-Hatem Dominique
• Mandonnet Emmanuel
• Polivka Marc
• Dorfmüller Georges
• Dauta Aurélie
• Desplanques Mathilde
• Gareton Albane
• Pages Mélanie
• Tauziede-Espariat Arnault
• Grill Jacques
• Bourdeaut Franck
• Doz François
• Dhermain Frédéric
• Mokhtari Karima
• Chretien Fabrice
• Figarella‑branger Dominique
• Varlet Pascale

keywords

• DNA-methylation analysis
• Glioblastoma
• Glioma
• Integrated diagnosis
• Whole exome sequencing

abstract

Considering that pediatric high-grade gliomas (HGGs) are biologically distinct from their adult counterparts, the objective of this study was to define the landscape of HGGs in adolescents and young adults (AYAs).

more information