High mitochondrial DNA copy number is associated with longer survival in young patients with glioblastoma


  • Dardaud Laure-Marie
  • Bris Céline
  • Desquiret-Dumas Valérie
  • Boisselier Blandine
  • Tabouret Emeline
  • Mokhtari Karima
  • Figarella-Branger Dominique
  • Rousseau Audrey
  • Procaccio Vincent


  • Glioblastoma
  • Mitochondrial genome
  • MtDNA copy number
  • Prognosis and survival
  • Young adults


Glioblastoma (GB) is the most common and most aggressive form of diffuse glioma, with a median overall survival of 15 months after standard of care.1 Young GB patients (<40 years old) may carry isocitrate dehydrogenase 1 or 2 (IDH1/2) mutations or, in rare instances, harbor H3F3A or HIST1H3B mutations. Other cases are wild-type for those genes and harbor gain of chromosome (chr) 7, loss of chr 10, and epidermal growth factor receptor (EGFR) amplification (amp). IDH1/2 mutations are associated with longer survival (24 mo), whereas...

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