Independent prognostic value of ultra-sensitive quantification of tumor pre-treatment T790M subclones in EGFR mutated non-small cell lung cancer (NSCLC) treated by first/second generation TKI, depends on variant allele frequency (VAF): Results of the French cooperative thoracic intergroup (IFCT) biomarkers France project

authors

  • Beau-Faller Michèle
  • Pencreach Erwan
  • Leduc Charlotte
  • Blons Hélène
  • Merlio Jean-Philippe
  • Bringuier Pierre-Paul
  • de Fraipont Florence
  • Escande Fabienne
  • Lemoine Antoinette
  • Ouafik l'Houcine
  • Denis Marc
  • Hofman Paul
  • Lacave Roger
  • Melaabi Samia
  • Langlais Alexandra
  • Missy Pascale
  • Morin Franck
  • Moro-Sibilot Denis
  • Barlesi Fabrice
  • Cadranel Jacques

keywords

  • Droplet digital PCR ddPCR
  • EGFR mutation
  • Non-small cell lung cancer NSCLC
  • T790M
  • Variant allele frequency VAF

document type

ART

abstract

T790M mutations inEGFR-mutated non-small cell lung cancer (NSCLC) account for nearly 50% of acquired resistance mechanisms to EGFR-TKIs. Earlier studies suggested that tumor T790M could also be detected in TKI-naïve EGFR-mutated NSCLC. The aim of the study is to assess the prevalence and clinical significance of quantification of tumor pre-treatment T790M subclones.

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