Dissociations between cognitive and motor effects of psychostimulants and atomoxetine in hyperactive DAT-KO mice


  • Del'Guidice Thomas
  • Lemasson Morgane
  • Etievant Adeline
  • Manta Stella
  • Magno Luiz Alexandre V
  • Escoffier Guy
  • Roman François
  • Beaulieu Jean-Martin
  • Del’guidice Thomas
  • Magno Luiz Alexandre V.

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Psychostimulants such as amphetamine and methylphenidate, which target the dopamine transporter (DAT), are the most frequently used drugs for the treatment of hyperactivity and cognitive deficits in humans with attention deficit hyperactivity disorder (ADHD). While psychostimulants can increase activity in healthy subjects, they exert a "paradoxical" calming effect in humans with ADHD as well as in hyperactive mice lacking the dopamine transporter (DAT-KO mice). However, the mechanism of action of these drugs and their impact on cognition in the absence of DAT remain poorly understood.

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