CDA as a predictive marker for life-threatening toxicities in patients with AML treated with cytarabine


  • Fanciullino Raphaelle
  • Farnault Laure
  • Donnette Mélanie
  • Imbs Diane-Charlotte
  • Roche Catherine
  • Venton Geoffroy
  • Berda-Haddad Yael
  • Ivanov Vadim
  • Ciccolini Joseph
  • Ouafik L’houcine
  • Lacarelle Bruno
  • Costello Régis

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Key Points Ara-C is the mainstay of treatment for patients with AML, and life-threatening toxicities are common. We demonstrated that cytidine deaminase downregulation predicts severe/lethal toxicities with cytarabine.

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