An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism

authors

  • Meziane Hamid
  • Schaller Fabienne
  • Bauer Sylvian
  • Villard Claude
  • Matarazzo Valéry
  • Riet Fabrice
  • Guillon Gilles
  • Lafitte Daniel
  • Desarménien Michel
  • Tauber Maïthe
  • Muscatelli Françoise

keywords

  • Autism spectrum disorder
  • MAGEL2
  • Neurodevelopment
  • Oxytocin
  • Prader-Willi syndrome
  • Therapy

document type

ART

abstract

Mutations of MAGEL2 have been reported in patients presenting with autism, and loss of MAGEL2 is also associated with Prader-Willi syndrome, a neurodevelopmental genetic disorder. This study aimed to determine the behavioral phenotype of Magel2-deficient adult mice, to characterize the central oxytocin (OT) system of these mutant mice, and to test the curative effect of a peripheral OT treatment just after birth.

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