NADPH Oxidase-1 Plays a Crucial Role in Hyperoxia-induced Acute Lung Injury in Mice


  • Carnesecchi Stéphanie
  • Deffert Christine
  • Pagano Alessandra
  • Garrido-Urbani Sarah
  • Métrailler-Ruchonnet Isabelle
  • Schäppi Michela
  • Donati Yves
  • Matthay Michael
  • Krause Karl-Heinz
  • Barazzone Argiroffo Constance


Hyperoxia-induced acute lung injury has been used for many years as a model of oxidative stress mimicking clinical acute lung injury and the acute respiratory distress syndrome. Excess quantities of reactive oxygen species (ROS) are responsible for oxidative stress-induced lung injury. ROS are produced by mitochondrial chain transport, but also by NADPH oxidase (NOX) family members. Although NOX1 and NOX2 are expressed in the lungs, their precise function has not been determined until now.

more information