cIMPACT-NOW (the consortium to inform molecular and practical approaches to CNS tumor taxonomy): a new initiative in advancing nervous system tumor classification


  • N.Louis David
  • Aldape Ken
  • Brat Daniel J.
  • Capper David
  • Ellison David
  • Hawkins Cynthia
  • Paulus Werner
  • Perry Arie
  • Reifenberger Guido
  • Figarella-Branger Dominique
  • Wesseling Pieter
  • Batchelor Tracy T.
  • Cairncross J. Gregory
  • Pfister Stefan
  • Rutkowski Stefan
  • Weller Michael
  • Wick Wolfgang
  • von Deimling Andreas


  • Brain tumors
  • Neuropathologiste
  • Classification of Tumors

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The 2016 World Health Organization Classification of Tumors of the Central Nervous System (2016 CNS WHO) is a major shift in the way neuropathologists analyze and diagnose brain tumors as it incorporates molecular and histological information together to define many entities (1). While the 2016 CNS WHO thereby facilitates more precise diagnosis of well-understood entities and clearer designation of less-understood entities, it also presents a number of practical challenges for neuropathologists, requiring substantial shifts in their day-to-day practices (2). Nonetheless, neuropathologiste will learn the system readily over time, and will adapt as needed to the new requirements.

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