MT5-MMP, just a new APP processing proteinase in Alzheimer's disease?


  • Baranger Kévin
  • Khrestchatisky Michel
  • Rivera Santiago

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We have recently identified in a transgenic mouse model of Alzheimer's ă disease (AD) membrane-type 5-MMP (MT5-MMP) as a new player in ă Alzheimer's pathogenesis, which displays pro-amyloidogenic features and ă proteolytic processing of amyloid precursor protein (APP). Another group ă has reported that MT5-MMP processing of APP may release a novel ă neurotoxic APP fragment. Although MT5-MMP-mediated APP processing ă appears to be a key pathogenic step, we hypothesize that MT5-MMP may ă also contribute to AD pathogenesis through complementary mechanisms that ă involve the activation of pro-inflammatory pathways and/or APP ă trafficking.

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