Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines


  • Montana Marc
  • Correard Florian
  • Khoumeri Omar
  • Esteve Marie-Anne
  • Terme Thierry
  • Vanelle Patrice


  • Anti-cancer drugs
  • Neuroblastoma
  • Oxirane
  • Quinoxaline
  • TDAE
  • XK469
  • Isatin

document type



Neuroblastoma is an aggressive pediatric malignancy with significant chemotherapeutic resistance. In order to obtain new compounds active on neuroblastoma cell lines, we investigated the reactivity of carbanion formed via TDAE in quinoxaline series. The new synthesized compounds were tested for their anti-proliferative activity on two neuroblastoma cell lines, and seven oxirane derivatives obtained interesting activities.

more information