Integrated multi-omics analysis of oligodendroglial tumours identifies three subgroups of 1p/19q co-deleted gliomas

authors

• Kamoun Aurélie
• Idbaih Ahmed
• Dehais Caroline
• Elarouci Nabila
• Carpentier Catherine
• Letouzé Eric
• Colin Carole
• Mokhtari Karima
• Jouvet Anne
• Uro-Coste Emmanuelle
• Martin-Duverneuil Nadine
• Sanson Marc
• Delattre Jean-Yves
• Figarella-Branger Dominique
• de Reyniès Aurélien
• Ducray François

document type

abstract

Oligodendroglial tumours (OT) are a heterogeneous group of gliomas. Three molecular subgroups are currently distinguished on the basis of the IDH mutation and 1p/19q co-deletion. Here we present an integrated analysis of the transcriptome, genome and methylome of 156 OT. Not only does our multi-omics classification match the current classification but also reveals three subgroups within 1p/19q co-deleted tumours, associated with specific expression patterns of nervous system cell types: oligodendrocyte, oligodendrocyte precursor cell (OPC) and neuronal lineage. We confirm the validity of these three subgroups using public datasets. Importantly, the OPC-like group is associated with more aggressive clinical and molecular patterns, including MYC activation. We show that the MYC activation occurs through various alterations, including MYC genomic gain, MAX genomic loss, MYC hypomethylation and microRNA-34b/c down-regulation. In the lower grade glioma TCGA dataset, the OPC-like group is associated with a poorer outcome independently of histological grade. Our study reveals previously unrecognized heterogeneity among 1p/19q co-deleted tumours.

more information