The Institute of NeuroPhysiopathology (INP) is a training and research centre of excellence that combines basic and translational research to study neural cell organisation, function and interaction, the molecular and cellular bases of major brain diseases, and to develop innovative cellular and molecular therapeutic strategies.
The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.
On 4 April, Nora Essakhi, Roberta Stacchini and Alexandre Bertucci, PhD students in the GlioME team, presented their poster at the 5th Scientific Annual Conference - Institut Cancer et Immunologie (ICI) on the theme of "CAR T cells, advances in cellular engineering and future challenges in cancer therapy".
Nora's work on "GD3, a promising therapeutic target for CAR-T cells against glioblastoma stem cells", was recognised by the scientific committee, which awarded her the prize for best poster. Well done Nora!
The review "GD3 ganglioside is a promising therapeutic target for glioma patients" is now published in Neuro-oncology Advances.
Congratulations to Victoria Hein, Nathalie Baeza-Kallee, Alexandre Bertucci, Carole Colin, Aurélie Tchoghandjian, Dominique Figarella-Branger, Emeline Tabouret for this work.
Salma Laftimi, a L3 student at AMU, joined Team 4 for her internship. She will stay with us for 1 month.
Welcome!
Dr Nasab Reda joins Team 6 as a post-doctoral researcher on a one-year project with an industrial partner.
She will be in charge of setting up a cellular model to study the effects of modulating a receptor of interest to the partner.
Congratulations to Nicolas Vermeersch, PhD student in Teams 4 and 6, who received a "bourse de recherche pour l'avancement de l'innovation en neurosciences de Novartis", BRAINNS.
Well done!
Céline joined the Neurocyto team on 04 March 2024.
She will study microtubules and their regeneration mechanism in primary neuronal cultures.
She is in the 3rd year of a biological engineering degree in medical biology and biotechnology at Clermont-Ferrand.
Chiara Bastiancich (GlioME) and Maud Gratuze (SynapTau) participated to the CNRS welcome day in Paris.
It was a great opportunity for them to meet the 770 other new recruits of the CNRS in 2023 and to get to know their new scientific ally better!
As part of the Brain Awareness Week 2024, Maud Gratuze from the "Synaptic degeneration and Gliosis" team has been invited to contribute to the webinar: "France Alzheimer: Hope in Research" organized by France Alzheimer association which took place on Tuesday, March 12th.
The videos will soon be on the France Alzheimer association's YouTube channel.
The NeuroCyto lab is looking to hire a postdoctoral fellow for an exciting project at the interface of microscopy and neuronal cell biology.
Deadline for application: January 15th, 2023. Starting date (flexible): April 2023.
About the position and project
On 4 April, Nora Essakhi, Roberta Stacchini and Alexandre Bertucci, PhD students in the GlioME team, presented their poster at the 5th Scientific Annual Conference - Institut Cancer et Immunologie (ICI) on the theme of "CAR T cells, advances in cellular engineering and future challenges in cancer therapy".
The review "GD3 ganglioside is a promising therapeutic target for glioma patients" is now published in Neuro-oncology Advances.
Congratulations to Victoria Hein, Nathalie Baeza-Kallee, Alexandre Bertucci, Carole Colin, Aurélie Tchoghandjian, Dominique Figarella-Branger, Emeline Tabouret for this work.
Salma Laftimi, a L3 student at AMU, joined Team 4 for her internship. She will stay with us for 1 month.
Welcome!
Dr Nasab Reda joins Team 6 as a post-doctoral researcher on a one-year project with an industrial partner.
She will be in charge of setting up a cellular model to study the effects of modulating a receptor of interest to the partner.
Congratulations to Nicolas Vermeersch, PhD student in Teams 4 and 6, who received a "bourse de recherche pour l'avancement de l'innovation en neurosciences de Novartis", BRAINNS.
Well done!
Céline joined the Neurocyto team on 04 March 2024.
She will study microtubules and their regeneration mechanism in primary neuronal cultures.
She is in the 3rd year of a biological engineering degree in medical biology and biotechnology at Clermont-Ferrand.
Chiara Bastiancich (GlioME) and Maud Gratuze (SynapTau) participated to the CNRS welcome day in Paris.
It was a great opportunity for them to meet the 770 other new recruits of the CNRS in 2023 and to get to know their new scientific ally better!
As part of the Brain Awareness Week 2024, Maud Gratuze from the "Synaptic degeneration and Gliosis" team has been invited to contribute to the webinar: "France Alzheimer: Hope in Research" organized by France Alzheimer association which took place on Tuesday, March 12th.
The videos will soon be on the France Alzheimer association's YouTube channel.
Gaelle Guiraudie Capraz from the NOSE Team met pupils from a CM1 and CM2 class at Jean Jaurès elementary school in Velaux as part of Brain Week.
We hope it will inspire the young one to become future researchers !
Matthew Lennol
"Deciphering apolipoprotein E-associated alterations in Alzheimer's Disease"
APOE, the gene encoding the apolipoprotein E (apoE) protein, is the most prominent genetic risk factor for sporadic AD. Although the APOE ε4 allelic variant is linked to increased risk of AD, it is likely that all isoforms are participating in the pathology to some degree. Other apoE-related proteins, including receptors and competitive ligands, such as reelin, may also play yet undescribed roles in AD. The following studies aim to characterise alterations in both apoE and reelin patterns in the cerebrospinal fluid of AD patients with the aim of developing new potential biomarkers for the pathology. We also describe a relatively unknown apoE receptor family member, LRP3, to try and elucidate novel pathways that may be participating in AD.
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