Two novel tumours with NTRK2 fusion in the methylation class of extraventricular neurocytomas, including one intraventricular

authors

• Uro-Coste Emmanuelle
• Tauziède-Espariat Arnault
• Dubucs Charlotte
• Chiforeanu Dan Christian
• Siegfried Aurore
• Nicaise Yvan
• Bauchet Luc
• Riffaud Laurent
• Bielle Franck
• Vasiljevic Alexandre
• Appay Romain
• Evrard Solène
• Varlet Pascale
• Rigau Valérie

abstract

We report here about two novel tumours classified as extraventricular neurocytomas (EVN) using DNA-methylation profiling, associated with NTRK2 fusions instead of the usual FGFR1 alterations so far attributed to this tumoural entity. We present the second detailed case of an intraventricular presentation in the MC EVN. Our findings broaden the spectrum of MC EVN and have implications in terms of diagnosis, therapy and terminology.

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