The genomic landscape of dysembryoplastic neuroepithelial tumours and a comprehensive analysis of recurrent cases

authors

• Pagès Mélanie
• Debily Marie-Anne
• Fina Frédéric
• Jones David
• Saffroy Raphael
• Castel David
• Blauwblomme Thomas
• Métais Alice
• Bourgeois Marie
• Lechapt-Zalcman Emmanuèle
• Tauziède-Espariat Arnault
• Andreiuolo Felipe
• Chrétien Fabrice
• Grill Jacques
• Boddaert Nathalie
• Figarella‑branger Dominique
• Beroukhim Rameen
• Varlet Pascale
• Debily Marie‐anne

keywords

• DNA methylation profiling
• FGFR1
• Dysembryoplastic neuroepithelial tumours
• Glioneuronal tumours
• Molecular pathology
• Paediatric low-grade gliomas

abstract

Dysembryoplastic neuroepithelial tumour (DNT) is a glioneuronal tumour that is challenging to diagnose, with a wide spectrum of histological features. Three histopathological patterns have been described: specific DNTs (both the simple form and the complex form) comprising the specific glioneuronal element, and also the non-specific/diffuse form which lacks it, and has unclear phenotype-genotype correlations with numerous differential diagnoses.

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