Characterization of the ability of a, second-generation SST-DA chimeric molecule, TBR-065, to suppress GH secretion from human GH-secreting adenoma cells

authors

• Cuny Thomas
• Graillon Thomas
• Defilles Célines
• Datta Rakesh
• Zhang Shengwen
• Figarella-Branger Dominique
• Dufour Henry
• Mougel Grégory
• Brue Thierry
• Landsman Tanya
• Halem Heather
• Culler Michael
• Barlier Anne
• Saveanu Alexandru

keywords

• Acromegaly
• Cabergoline
• Dopastatin
• Octreotide
• TBR-065

document type

abstract

Somatostatin (SST) and dopamine (DA) inhibit growth hormone (GH) secretion and proliferation of GH-secreting pituitary adenomas (GHomas) through binding to SSTR2 and D2R receptors. Chimeric SST-DA compounds (Dopastatins) display increased potency in inhibiting GH secretion, as compared with individual SST or DA analogs (alone or combined).

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