Association of patterns of care, prognostic factors, and use of radiotherapy–temozolomide therapy with survival in patients with newly diagnosed glioblastoma: a French national population-based study

authors

• Fabbro-Peray Pascale
• Zouaoui Sonia
• Darlix Amelie
• Fabbro Michel
• Pallud Johan
• Rigau Valérie
• Mathieu-Daudé Hélène
• Bessaoud Faïza
• Bauchet Fabienne
• Riondel Adeline
• Sorbets Elodie
• Charissoux Marie
• Amelot Aymeric
• Mandonnet Emmanuel
• Figarella-Branger Dominique
• Duffau Hugues
• Tretarre Brigitte
• Taillandier Luc
• Bauchet Luc

keywords

• Clinical epidemiology
• Glioblastoma
• Neuro-oncology
• Neurosurgery
• Population-based study
• Temozolomide

abstract

BACKGROUND:Glioblastoma is the most frequent primary malignant brain tumor. In daily practice and at whole country level, oncological care management for glioblastoma patients is not completely known.OBJECTIVES:To describe oncological patterns of care, prognostic factors, and survival for all patients in France with newly-diagnosed and histologically confirmed glioblastoma, and evaluate the impact of extended temozolomide use at the population level.METHODS:Nationwide population-based cohort study including all patients with newly-diagnosed and histologically confirmed glioblastoma in France in 2008 and followed until 2015.RESULTS:Data from 2053 glioblastoma patients were analyzed (male/female ratio 1.5, median age 64 years). Median overall survival (OS) was 11.2 [95% confidence interval (CI) 10.7-11.9] months. The first-line therapy and corresponding median survival (MS, in months) were: 13% did not receive any oncological treatment (biopsy only) (MS = 1.8, 95% CI 1.6-2.1), 27% received treatment without the combination of radiotherapy (RT)-temozolomide (MS = 5.9, 95% CI 5.5-6.6), 60% received treatment including the initiation of the concomitant phase of RT-temozolomide (MS = 16.4, 95% CI 15.2-17.4) whom 44% of patients initiated the temozolomide adjuvant phase (MS = 18.9, 95% CI 18.0-19.8). Only 22% patients received 6 cycles or more of adjuvant temozolomide (MS = 25.5, 95% CI 24.0-28.3). The multivariate analysis showed that the risk of mortality was significantly higher for the non-progressive patients who stopped at 6 cycles (standard protocol) than those who continued the treatment, hazard ratio = 1.5 (95% CI 1.2-1.9).CONCLUSION:In non-progressive patients, prolonging the adjuvant temozolomide beyond 6 cycles may improve OS.

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