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authors
- Beau-Faller Michèle
- Pencreach Erwan
- Leduc Charlotte
- Blons Hélène
- Merlio Jean-Philippe
- Bringuier Pierre-Paul
- de Fraipont Florence
- Escande Fabienne
- Lemoine Antoinette
- Ouafik L'Houcine
- Denis Marc
- Hofman Paul
- Lacave Roger
- Melaabi Samia
- Langlais Alexandra
- Missy Pascale
- Morin Franck
- Moro-Sibilot Denis
- Barlesi Fabrice
- Cadranel Jacques
keywords
- Variant allele frequency VAF
- T790M
- Non-small cell lung cancer NSCLC
- Droplet digital PCR ddPCR
- EGFR mutation
document type
ART
abstract
T790M mutations inEGFR-mutated non-small cell lung cancer (NSCLC) account for nearly 50% of acquired resistance mechanisms to EGFR-TKIs. Earlier studies suggested that tumor T790M could also be detected in TKI-naïve EGFR-mutated NSCLC. The aim of the study is to assess the prevalence and clinical significance of quantification of tumor pre-treatment T790M subclones.
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