An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism

authors

• Meziane Hamid
• Schaller Fabienne
• Bauer Sylvian
• Villard Claude
• Matarazzo Valéry
• Riet Fabrice
• Guillon Gilles
• Lafitte Daniel
• Desarménien Michel G
• Tauber Maïthé
• Muscatelli Françoise

keywords

• Autism spectrum disorder
• MAGEL2
• Neurodevelopment
• Oxytocin
• Prader-Willi syndrome
• Therapy

abstract

Mutations of MAGEL2 have been reported in patients presenting with autism, and loss of MAGEL2 is also associated with Prader-Willi syndrome, a neurodevelopmental genetic disorder. This study aimed to determine the behavioral phenotype of Magel2-deficient adult mice, to characterize the central oxytocin (OT) system of these mutant mice, and to test the curative effect of a peripheral OT treatment just after birth.

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