Peripherally Applied Synthetic Tetrapeptides HAEE and RADD Slow Down the Development of Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice

authors

• Tsvetkov Philipp A
• Cheglakov Ivan B
• Ovsepyan Armen A
• Mediannikov Oleg O
• Morozov Alexander A
• Telegin Georgy B
• Kozin Sergey A

keywords

• Alzheimer's disease
• Amyloid- β
• Mouse models
• Protein aggregation in vivo

abstract

Two tetrapeptides, HAEE and RADD, which are ionic-complementary to the primary zinc recognition site of amyloid-(A), have been reported to inhibit zinc-induced dimerization of the A metal-binding domain and slow A aggregation in vitro. In the present study, we investigate the impact of HAEE and RADD on the development of cerebral-amyloidosis in a mouse model of Alzheimer's disease. We have found chronic intravenous administration of each peptide results in significant decrease of amyloid plaque burden in the treated mice.

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